5-Amino-1MQ – Research Grade NNMT Inhibitor

Product Overview

5-Amino-1MQ is a high-purity research-grade small molecule widely used in scientific studies investigating Nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide metabolism, methylation pathways, and cellular energy regulation. Due to its selectivity for NNMT, 5-Amino-1MQ has become an important research tool in studies exploring adipocyte biology, metabolic regulation, mitochondrial function, and NAD⁺ metabolism.

At BioWellLab.uk, every batch of 5-Amino-1MQ is manufactured to stringent research-grade standards and undergoes analytical quality testing to help ensure identity, purity, and consistency. This product is supplied exclusively for laboratory and scientific research by qualified professionals.

What is 5-Amino-1MQ?

5-Amino-1MQ is a selective inhibitor of Nicotinamide N-methyltransferase (NNMT). NNMT is an intracellular enzyme that participates in nicotinamide metabolism by catalyzing the methylation of nicotinamide. Because NNMT activity has been linked to cellular metabolism and energy homeostasis, it has become an important focus in biochemical and metabolic research.

Current laboratory studies continue to investigate how selective NNMT inhibition influences intracellular NAD⁺ metabolism, lipid metabolism, mitochondrial activity, and other biochemical pathways. These investigations remain primarily in preclinical and laboratory settings.

Mechanism of Action

5-Amino-1MQ acts as a selective NNMT inhibitor. In laboratory studies, inhibition of NNMT has been associated with changes in:

• Nicotinamide metabolism
• Cellular methylation pathways
• NAD⁺ availability
• Energy metabolism
• Adipocyte differentiation
• Lipid metabolism
• Mitochondrial function

Researchers continue to investigate these biological mechanisms to better understand the role of NNMT in cellular physiology and metabolic regulation.

Scientific Research

Interest in 5-Amino-1MQ has grown because of its use as a research tool in studies examining NNMT biology. Experimental laboratory and animal studies have reported that selective NNMT inhibition can alter intracellular nicotinamide metabolism, reduce 1-methylnicotinamide production, increase NAD⁺ availability, and influence adipocyte biology under controlled experimental conditions.

Additional review articles describe NNMT as an emerging metabolic target and summarize ongoing research into its role in obesity, type 2 diabetes, cardiovascular biology, skeletal muscle physiology, and cancer metabolism. These publications also emphasize that much of the evidence remains preclinical and that further research is required to establish clinical relevance.

Research Applications

Researchers commonly investigate 5-Amino-1MQ in studies involving:

• NNMT inhibition
• Cellular metabolism
• Energy homeostasis
• NAD⁺ metabolism
• Adipocyte biology
• Lipid metabolism
• Mitochondrial function
• Molecular biology
• Biochemistry
• Pharmaceutical discovery

This product is intended solely for laboratory research and analytical applications.

Product Specifications

Available Variations

5mg × 10 Vials – Suitable for exploratory laboratory studies and analytical investigations.

10mg × 10 Vials – Designed for expanded experimental protocols requiring a higher amount of research material.

50mg × 10 Vials – Intended for laboratories conducting larger-scale or ongoing research projects.

Quality Assurance

Every BioWellLab.uk product is manufactured under strict quality standards. Each batch undergoes analytical testing, and supporting documentation such as a Certificate of Analysis (COA) and analytical reports may be provided to support research quality requirements.

Storage

Store unopened vials under recommended laboratory conditions. For long-term stability, refrigerated or frozen storage is generally recommended. Avoid repeated freeze-thaw cycles after reconstitution.

Frequently Asked Questions

What is 5-Amino-1MQ?

5-Amino-1MQ is a selective NNMT inhibitor supplied for laboratory and scientific research.

What purity does BioWellLab.uk provide?

Greater than 99% purity.

What strengths are available?

• 5mg × 10 Vials
• 10mg × 10 Vials
• 50mg × 10 Vials

Is this product intended for human use?

No. This product is supplied exclusively for laboratory research and is not intended for human or veterinary use.

Scientific References

1. PubChem – 5-Amino-1MQ
   https://pubchem.ncbi.nlm.nih.gov/
2. NCBI (National Center for Biotechnology Information)
   https://www.ncbi.nlm.nih.gov/
3. PubMed – NNMT Research
   https://pubmed.ncbi.nlm.nih.gov/
4. Journal of Medicinal Chemistry
   https://pubs.acs.org/journal/jmcmar
5. Nature
   https://www.nature.com/

Research Use Only

This product is supplied strictly for laboratory, analytical, and scientific research purposes only. It is not intended for human consumption, veterinary use, diagnosis, treatment, cure, or prevention of disease. BioWellLab.uk products are to be handled only by qualified research professionals.